Regina Joice Cordy

Assistant Professor of Biology

Education:

B.A. University of Virginia (2006)
Ph.D. Harvard University (2013)
Postdoctoral Training. Harvard School of Public Health (2015)
Postdoctoral Training. Emory University (2018)

Office:

211 Winston Hall
(336)-758-5566
cordyrj at wfu.edu

Areas of Interest:

malaria pathogenesis, host-parasite interactions, human microbiome

Research Interests:

My research focuses on the pathogenesis of the protozoan parasite Plasmodium, the etiological agent of malaria. The development of severe malaria is a multi-factorial process that is not well understood. In addition to host genetics and immunity, host factors such as the microbiome, metabolism and diet may explain some of the heterogeneity observed in malaria disease outcome, but much less is known about the role of these factors. My research involves a combination of laboratory, computational and field-based approaches to investigate this topic. Specific areas of research include the study of host-parasite interactions in tissue using histology and molecular biology approaches, and the analysis of plasma metabolome and gut microbiome data to identify key physiological perturbations that occur during malaria infection.

Select publications:

^†Last name changed from Joice to Cordy in August 2016.
*These authors contributed equally to this publication

My full list of publications can be found here: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/50486701/?sort=date&direction=descending

Malaria pathogenesis:

Gardinassi LG, Arévalo-Herrera M, Herrera S, Cordy RJ, Tran V, Smith MR, Johnson MS, Chacko B, Liu KH, Darley-Usmar VM, Go YM, Jones DP, Galinski MR, Li S. “Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling.” Redox biology. 2018; 17:158-170.

Gardinassi LG, Cordy RJ, Lacerda MVG, Salinas JL, Monteiro WM, Melo GC, Siqueira AM, Val FF, Tran V, Jones DP, Galinski MR, Li S. “Metabolome-Wide Association Study of Peripheral Parasitemia in Plasmodium vivax Malaria.” International Journal of Medical Microbiology. 2017. 2017.09.002.

Joice R^†, Frantzreb C, Pradham A, Seydel KB, Kamiza S, Wirth D, Duraisingh MT, Molyneux ME, Taylor TE, Marti M, Milner DA. “Splenic pathology supports the acceleration of cerebral malaria through HIV infection in a subset of pediatric patients.” Modern Pathology. 2016. Apr;29(4):381-90.

Joice R^†, Nilsson SK, Montgomery J, Dankwa S, Egan E, Morahan B, Seydel KB, Bertuccini L, Alano P, Williamson KC, Duraisingh MT, Taylor TE, Milner DA, Marti M. “Plasmodium falciparum transmission stages sequester in the hematopoietic system of the human bone marrow.” Science Translational Medicine. 2014 Jul 9;6(244):244re5.

Human microbiome:

Hsu T^*, Joice R^†*, Vallarino J, Abu-Ali G, Hartmann EM, Shafquat A, DuLong C, Baranowski C, Gevers D, Green JL, Morgan XC, Spengler JD, Huttenhower CH. “Urban Transit System Microbial Communities Differ by Surface Type and Interaction with Humans and the Environment”. mSystems Jun 2016, 1 (3) e00018-16.

Joice R^†, Yasuda K, Shafquat A, Morgan XC, Huttenhower C. “Determining microbial products and identifying molecular targets in the human microbiome.” Cell Metabolism. 2014 Nov 4;20(5):731-41.

Mathematical modeling:

Joice R^†*, Narasimhan V^*, Montgomery J, Sidhu AB, Oh K, Meyer E, Pierre-Louis W, Seydel K, Milner D, Williamson K, Wiegand R, Ndiaye D, Daily J, Wirth D, Taylor T, Huttenhower C, Marti M. “Inferring Developmental Stage Composition From Gene Expression in Human Malaria.” PLoS Computational Biology 2013;9(12):e1003392.

Joice R^†, Lipsitch M. “Targeting Imperfect Vaccines Against Drug-Resistance Determinants: a Strategy for Countering the Rise of Drug Resistance.” PLoS One. 2013 Jul 25;8(7):e68940.